50L ATEX Custom Solid-Phase Peptide Synthesizer

Our 50L ATEX Custom Solid-Phase Peptide Synthesizer elevates polypeptide synthesis process for demanding industrial and research environments. 

Crafted entirely from corrosion-resistant 316L stainless steel, this robust system is built for longevity and purity-critical applications.

Volume: 10L, 20L, 30L, 50L, 100L, 200L, 300L, 500L and more.

Vessel: Single wall, double wall available.

Working pressure: Full vacuum to Positive pressure

Working temperature: -80°C ~ +220°C, support customization

Filter device: PTFE, glass or stainless-steel, pore size 0.1um to 200um

What is a Solid-phase Peptide Synthesizer (SPPS) ?

A Solid-Phase Peptide Synthesizer (SPPS) is a specialized chemical reactor designed for the step-by-step synthesis of peptide chains. 

Molecules are built sequentially while anchored to insoluble polymer resin beads within the reaction vessel, enabling precise control and efficient purification.

Technical Specifications

ModelSFR-10LSFR-20LSFR-30LSFR-50LSFR-100LSFR-200LSFR-300LSFR-500LSFR-1000L
Material Capacity (L)102030501002003005001000
Jacket Volume (L)≈5≈6≈10≈15≈25≈35≈60≈100≈200
Lid Ports6 standard ports: sight glass, solid charging/observation port, liquid feed port,
temperature probe port, agitator port, and spare port. Custom configurations available.
Variable Frequency Drive (VFD)Digital display of temperature and agitation speed
Agitation Speed (rpm)0–4000–2800–180
Shaft SealSelf-lubricating mechanical seal; optional sleeve-type mechanical seal
or magnetic coupling seal
Agitator ConfigurationSingle-stage propeller impellerDouble-stage propeller impeller
Filter Plate MaterialStandard: 316L stainless steel; optional titanium alloy, glass,
or other materials
Filter Pore SizeStandard: 40–60 μm; customizable: 1–160 μm
Motor Power / Gear Ratio180 W / 1:3370 W / 1:5550 W / 1:5750 W / 1:7.51.5 kW / 1:7.53 kW / 1:7.5
Power Supply220 V / 50 Hz; voltage can be customized according to customer requirements
CertificationCE

Key Features & Advantages

  • Large-Scale Capacity: A generous 50L reaction vessel empowers high-yield peptide production.

  • Premium Construction: Entirely 316L stainless steel construction ensures superior chemical resistance and product integrity.

  • Enhanced Process Visibility: Features a large glass viewport on the vessel for real-time visual monitoring of the solid-phase resin and reaction progress.

  • Optimized Mixing: Equipped with a widened frame agitator specifically designed for efficient mixing and gentle handling of solid-phase resin beads in large volumes.

  • Intrinsic Safety: ATEX-certified explosion-proof motor and control panel guarantee safe operation in potentially explosive atmospheres involving flammable solvents or powders.

  • Superior Corrosion Defense: The support frame is Teflon-coated for exceptional protection against aggressive chemical vapors and spills.

  • Jacketed Temperature Control: Integrated jacket design allows precise heating or cooling of the reaction mixture using external circulators.

  • Effortless Material Handling: Includes a height-adjustable trolley specifically engineered for the safe, ergonomic unloading and transfer of solid peptide-resin or waste materials.

This custom SPPS is the ideal solution for pharmaceutical development, large-scale API production, and advanced research labs requiring safety-certified, reliable, and high-capacity peptide synthesis under rigorous conditions.

Structure of 50L Solid-Phase Peptide Synthesizer

Large glass viewport on the vessel for real-time visual monitoring

Customizable openings on the SPPS reactor lid

Big sight window

Widened frame agitator specifically designed for efficient mixing

Liftable trolley

Liftable trolley for solid material collection and transportation, very convenient !

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