Our 600L Industrial Stainless-steel Nutsche Filter Reactor is engineered for demanding large-scale peptide manufacturing and other critical solid-phase synthesis.
Built for performance, durability, and operator safety, this reactor integrates reaction and filtration in a single, robust unit.
Volume: 10L, 20L,30L, 50L, 100L, 200L,300L, 500L and more.
Vessel: Single wall, double wall available
Working pressure: Full vacuum to Positive pressure
Working temperature: -80°C ~ +220°C, support customization
Filter device: PTFE, glass or stainless-steel, pore size 0.1um to 200um
Technical Specifications
| Model | SFR-10L | SFR-20L | SFR-30L | SFR-50L | SFR-100L | SFR-200L | SFR-300L | SFR-500L | SFR-1000L |
|---|---|---|---|---|---|---|---|---|---|
| Material Capacity (L) | 10 | 20 | 30 | 50 | 100 | 200 | 300 | 500 | 1000 |
| Jacket Volume (L) | ≈5 | ≈6 | ≈10 | ≈15 | ≈25 | ≈35 | ≈60 | ≈100 | ≈200 |
| Lid Ports | 6 standard ports: sight glass, solid charging/observation port, liquid feed port, temperature probe port, agitator port, and spare port. Custom configurations available. | ||||||||
| Variable Frequency Drive (VFD) | Digital display of temperature and agitation speed | ||||||||
| Agitation Speed (rpm) | 0–400 | 0–280 | 0–180 | ||||||
| Shaft Seal | Self-lubricating mechanical seal; optional sleeve-type mechanical seal or magnetic coupling seal | ||||||||
| Agitator Configuration | Single-stage propeller impeller | Double-stage propeller impeller | |||||||
| Filter Plate Material | Standard: 316L stainless steel; optional titanium alloy, glass, or other materials | ||||||||
| Filter Pore Size | Standard: 40–60 μm; customizable: 1–160 μm | ||||||||
| Motor Power / Gear Ratio | 180 W / 1:3 | 370 W / 1:5 | 550 W / 1:5 | 750 W / 1:7.5 | 1.5 kW / 1:7.5 | 3 kW / 1:7.5 | |||
| Power Supply | 220 V / 50 Hz; voltage can be customized according to customer requirements | ||||||||
| Certification | CE | ||||||||
What is a Solid-phase Peptide Synthesis (SPPS) Reactor ?
An Industrial Solid-phase Peptide Synthesis (SPPS) Reactor is a specialized vessel designed for the efficient, scalable, and safe production of peptides using the solid-phase methodology.
In this process, peptide chains are synthesized step-by-step onto solid resin beads anchored within the reactor, enabling precise control and simplified purification in a stainless-steel nutsche filter reactor.
Key Specifications & Features
Optimized Capacity: 600L working volume for significant batch production.
Premium Construction: Double-layer vessel body made entirely of corrosion-resistant 316L stainless steel, ensuring product purity and longevity.
Versatile Lid Design: Features an 8-port lid for easy integration of agitators, thermometers, condensers, reagent addition lines, inert gas inlets, sampling valves, and monitoring devices.
Robust Agitation System: Driven by a powerful 3KW, 1:23 ratio explosion-proof motor coupled to an explosion-proof variable speed gear reducer. Equipped with a heavy-duty 316L stainless steel frame anchor stirrer supported by a substantial 60mm shaft diameter for reliable mixing of viscous slurries and resin beds.
Integrated Filtration: High-quality 316L stainless steel filter plate with a precise 40-60 micron pore size enables efficient solid-liquid separation (filtration, washing) directly within the reactor vessel (Nutsche principle).
Safety First: Critical components (motor, reducer) are certified explosion-proof, making this reactor suitable for use with flammable solvents common in SPPS.
This 600L Nutsche Filter Reactor represents the ideal solution for pharmaceutical, biotechnology, and fine chemical industries seeking reliable, safe, and efficient equipment for large-scale solid-phase synthesis.
Its combination of high-grade materials, powerful agitation, integrated filtration, and intrinsic safety features delivers superior process control and product quality.
Structure of HJCHEM 600L Industrial Solid-phase Reactor
Customizable openings on the SPPS reactor lid
Suitable stirring shaft and motor for your process
Quick open solid material feeding port
Customizable bottom valve to integrate with your production system